Ascorbic Acid (Vitamin C) Infusion in Human Sepsis

Phase 1/2 Completed 24 enrolled Virginia Commonwealth University

RandomizedSingle-groupQuadruple-blindTreatment

Summary

The major goal of this project is to determine whether intravenously infused ascorbic acid is safe for use as a viable therapeutic strategy in adult humans with sepsis.

Timeline

Start: 2010-05
Primary completion: 2012-09
Completion: 2012-09

Publications

Fowler AA 3rd, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, Gupta S; Medical Respiratory Intensive Care Unit Nursing; Fisher BJ, Natarajan R. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014 Jan 31;12:32. doi: 10.1186/1479-5876-12-32.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Vitamin C	Other / unclassified	50 mg/kg	Intravenous
Comparator	Vitamin C	Other / unclassified	200 mg/kg	Intravenous

Ascorbic Acid (Vitamin C) Infusion in Human Sepsis

Summary

Timeline

Publications

Drugs

Indications