drugset / Trial / NCT01437293
Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE)
Phase 1
Completed
15 enrolled
New York State Psychiatric Institute
Columbia University · collabNational Institute on Drug Abuse (NIDA) · collab
NaSingle-groupSingle-blindBasic science
Summary
An inpatient safety study to characterize the cardiovascular and behavioral effects of cocaine administration in the presence of LCE. The proposed study involves an inpatient stay of 12 days during which participants will have two cocaine-administration sessions, each including five doses of smoked cocaine with ascending doses.
Timeline
- Start
- 2010-08
- Primary completion
- 2012-04
- Completion
- 2012-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carbidopa | Unknown | 100 mg | — |
| Subject | Entacapone | Small molecule | 200 mg | — |
| Subject | L-dopa | Peptide | 400 mg | — |