drugset / Trial / NCT01438307

Phase II Study of Cabazitaxel-XRP6258 in Advanced Non-Small Cell Lung Cancer

NCT01438307

RandomizedParallel-groupOpen-labelTreatment

Summary

Lung cancer is the leading cause of cancer death worldwide and in the United States. The majority of lung cancers are non-small cell lung cancer (NSCLC). The majority of NSCLC cases are advanced at the time of diagnosis. Chemotherapy has improved overall survival but remains limited at \< 12 months median overall survival. New approaches are needed for second line chemotherapy treatment. Cabazitaxel-XRP6258 has shown increased overall survival in metastatic prostate cancer and it is hopeful it can do the same in advanced NSCLC.

Timeline

Start
2011-09
Primary completion
2014-09
Completion
2015-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Cabazitaxel Other / unclassified 10 mg/m2 Intravenous
Subject Cabazitaxel Other / unclassified 25 mg/m2 Intravenous