Study of Investigational Pneumococcal Vaccine in Healthy Adults, Toddlers and Infants

Summary

This study is designed to explore the safety and tolerability of an investigational pneumococcal vaccine through a step-down enrollment. Primary Objective: * To evaluate the safety and tolerability of an investigational pneumococcal vaccine. Secondary Objective: * To evaluate the immunogenicity of an investigational pneumococcal vaccine.

Timeline

Start

2011-09

Primary completion

2013-03

Completion

2013-06

Publications

• Results Brooks WA, Chang LJ, Sheng X, Hopfer R; PPR02 Study Team. Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study. Vaccine. 2015 Aug 26;33(36):4610-7. doi: 10.1016/j.vaccine.2015.06.078. Epub 2015 Jul 2.

Drugs

Indications