drugset / Trial / NCT01452607
Study to Evaluate the Safety and Pharmacokinetics of SPI-1005
RandomizedParallel-groupQuadruple-blindTreatment
Summary
A study to determine the safety, tolerability, and pharmacokinetics of SPI-1005 capsules in healthy adults.
Timeline
- Start
- 2006-05
- Primary completion
- 2006-08
- Completion
- 2006-08
Publications
- Results Lynch E, Kil J. Development of Ebselen, a Glutathione Peroxidase Mimic, for the Prevention and Treatment of Noise-Induced Hearing Loss. Semin Hear 2009; 30(1): 047-055
- Garland M, Hryckowian AJ, Tholen M, Bender KO, Van Treuren WW, Loscher S, Sonnenburg JL, Bogyo M. The Clinical Drug Ebselen Attenuates Inflammation and Promotes Microbiome Recovery in Mice after Antibiotic Treatment for CDI. Cell Rep Med. 2020 Apr 21;1(1):100005. doi: 10.1016/j.xcrm.2020.100005.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ebselen | Small molecule | 200 mg | Oral |
| Subject | Ebselen | Small molecule | 400 mg | Oral |
| Subject | Ebselen | Small molecule | 800 mg | Oral |
| Subject | Ebselen | Small molecule | 1600 mg | Oral |