drugset / Trial / NCT01468571
Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension
Phase 4
Unknown
50 enrolled
Baylor College of Medicine
National Heart, Lung, and Blood Institute (NHLBI) · collab
RandomizedCrossoverTriple-blindTreatment
Summary
The purpose of this study is to determine the effects of spironolactone on collagen markers in a large number of patients with pulmonary hypertension. In addition, safety and tolerability of spironolactone, an aldosterone receptor antagonist, in patients with pulmonary arterial hypertension, will be determined.
Timeline
- Start
- 2011-07
- Primary completion
- 2015-07
- Completion
- 2015-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Spironolactone | Small molecule | 50 mg | Oral |