Worms for Immune Regulation of Multiple Sclerosis

Phase 2 Completed 72 enrolled University of Nottingham National Multiple Sclerosis Society · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether people with MS who are exposed to a small number of hookworms will have less inflammation and less MS disease activity.

Timeline

Start: 2011-12
Primary completion: 2016-01
Completion: 2016-01

Outcome

Missed primary endpoint

paper The primary outcome did not reach significance, likely because of a low level of disease activity. PMID 32539079 ↗

Publications

Tanasescu R, Tench CR, Constantinescu CS, Telford G, Singh S, Frakich N, Onion D, Auer DP, Gran B, Evangelou N, Falah Y, Ranshaw C, Cantacessi C, Jenkins TP, Pritchard DI. Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial. JAMA Neurol. 2020 Sep 1;77(9):1089-1098. doi: 10.1001/jamaneurol.2020.1118.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hookworm larvae	Other / unclassified	25 unknown	Other