Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota

Completed 53 enrolled Beth Israel Deaconess Medical Center Biocodex · collab

RandomizedParallel-groupOpen-labelBasic science

Summary

The purpose of this study is to compare and contrast the effects of the probiotic Saccharomyces boulardii, the antibiotic amoxicillin/clavulanate and the combination on the gut microbiota of healthy volunteers.

Timeline

Start: 2012-04
Primary completion: 2013-02
Completion: 2013-02

Publications

Kelly CP, Chong Nguyen C, Palmieri LJ, Pallav K, Dowd SE, Humbert L, Seksik P, Bado A, Coffin B, Rainteau D, Kabbani T, Duboc H. Saccharomyces boulardii CNCM I-745 Modulates the Fecal Bile Acids Metabolism During Antimicrobial Therapy in Healthy Volunteers. Front Microbiol. 2019 Mar 4;10:336. doi: 10.3389/fmicb.2019.00336. eCollection 2019.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Amoxicillin	Other / unclassified	875 mg	—
Comparator	Clavulanate	Unknown	125 mg	—

Indications

No indication recorded.