Effects of Glutamine in Ischemic Heart Disease Patients Following Cardiopulmonary Bypass

Phase 3 Completed 24 enrolled Meshalkin Research Institute of Pathology of Circulation

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine whether perioperative glutamine administration possess protective properties on internal organs (heart and gut) in patients with coronary atherosclerosis, operated under cardiopulmonary bypass.

Timeline

Start: 2012-01
Primary completion: 2012-12
Completion: 2013-09

Publications

Background Lomivorotov VV, Efremov SM, Shmirev VA, Ponomarev DN, Lomivorotov VN, Karaskov AM. Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass. Heart Surg Forum. 2011 Dec;14(6):E384-8. doi: 10.1532/HSF98.20111074.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N(2)-L-Alanine L-Glutamine dipeptide	Peptide	2 g/kg	Intravenous

Effects of Glutamine in Ischemic Heart Disease Patients Following Cardiopulmonary Bypass

Summary

Timeline

Publications

Drugs

Indications