drugset / Trial / NCT01478828
Pre-Prostatectomy Lovastatin on Prostate Cancer
Terminated
2 enrolled
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Patrick C Walsh Prostate Cancer Research Fund · collab
NaSingle-groupOpen-labelTreatment
Summary
To determine the dose of continuous daily oral lovastatin needed to achieve MYC \[v-myc myelocytomatosis viral oncogene homolog (avian)\] down-regulation in prostatectomy specimens in intermediate-/high-risk localized prostate cancer patients.
Timeline
- Start
- 2012-07-13
- Primary completion
- 2013-04-08
- Completion
- 2013-04-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lovastatin | Small molecule | 1 mg/kg | Oral |
| Subject | Lovastatin | Small molecule | 4 mg/kg | Oral |
| Subject | Lovastatin | Small molecule | 8 mg/kg | Oral |
| Subject | Lovastatin | Small molecule | 10 mg/kg | Oral |
| Subject | Lovastatin | Small molecule | 12 mg/kg | Oral |
| Subject | Lovastatin | Small molecule | 20 mg/kg | Oral |