drugset / Trial / NCT01479634
Early HIV Therapy in Patients With High CD4 Cell Counts
Completed
279 enrolled
University of California, San Francisco
Infectious Diseases Research Collaboration, Uganda · collabMakerere University · collabMakerere University Joint AIDS Program · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
A study of antiretroviral therapy (ART) initiation under a "streamlined model of care" in HIV-positive patients with CD4+ cell counts greater ≥ 250 cells/uL
Timeline
- Start
- 2011-10
- Primary completion
- 2015-06
- Completion
- 2015-06
Publications
- Results Jain V, Byonanebye DM, Amanyire G, Kwarisiima D, Black D, Kabami J, Chamie G, Clark TD, Rooney JF, Charlebois ED, Kamya MR, Havlir DV; SEARCH Collaboration. Successful antiretroviral therapy delivery and retention in care among asymptomatic individuals with high CD4+ T-cell counts above 350 cells/mul in rural Uganda. AIDS. 2014 Sep 24;28(15):2241-9. doi: 10.1097/QAD.0000000000000401.
- Jain V, Chang W, Byonanebye DM, Owaraganise A, Twinomuhwezi E, Amanyire G, Black D, Marseille E, Kamya MR, Havlir DV, Kahn JG. Estimated Costs for Delivery of HIV Antiretroviral Therapy to Individuals with CD4+ T-Cell Counts >350 cells/uL in Rural Uganda. PLoS One. 2015 Dec 3;10(12):e0143433. doi: 10.1371/journal.pone.0143433. eCollection 2015.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Efavirenz | Other / unclassified | — | — |
| Comparator | Tenofovir disoproxyl fumarate | Unknown | — | Oral |
| Comparator | emtricitabine | Other / unclassified | — | Oral |