A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma

Summary

This is a non-randomized open label multicentre Phase II trial to evaluate the response rate of PF03446962 in patients with advanced malignant pleural mesothelioma who have been previously treated with cytotoxic chemotherapy.

Timeline

Start

2012-06-26

Primary completion

2014-04-27

Completion

2015-02-13

Outcome

Missed primary endpoint

paper The trial did not meet the prespecified response criterion for moving to the second stage. PMID 27449804 ↗

Publications

• Results Wheatley-Price P, Chu Q, Bonomi M, Seely J, Gupta A, Goss G, Hilton J, Feld R, Lee CW, Goffin JR, Maksymiuk A, Murray N, Hagerman L, Bradbury PA. A Phase II Study of PF-03446962 in Patients with Advanced Malignant Pleural Mesothelioma. CCTG Trial IND.207. J Thorac Oncol. 2016 Nov;11(11):2018-2021. doi: 10.1016/j.jtho.2016.06.024. Epub 2016 Jul 20.

Drugs

Indications