Effect of Febuxostat on Blood Pressure

Summary

The purpose of this study is to evaluate the effect of febuxostat, once daily (QD), compared to placebo on lowering ambulatory 24-hour mean blood pressure of participants with hypertension and hyperuricemia (not associated with gout).

Timeline

Start

2012-02

Primary completion

2014-08

Completion

2014-08

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Placebo vs Febuxostat 80 mg; p = 0.882; Least Squares Mean Difference -0.3 (95% CI -3.9 to 3.4); ANCOVA NCT01496469 ↗

Publications

• Gunawardhana L, McLean L, Punzi HA, Hunt B, Palmer RN, Whelton A, Feig DI. Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study. J Am Heart Assoc. 2017 Nov 4;6(11):e006683. doi: 10.1161/JAHA.117.006683.

Drugs

Indications