Drug-Drug Interaction Study With Pravastatin and Cyclosporine

Summary

This study will address the following question: Does cyclosporine affect the pharmacokinetics of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the organic anion transporter required for pravastatin transport into the liver, thus increasing pravastatin levels in the blood. The investigators hypothesize that this inhibition will vary among people based on genetic differences. This knowledge is important to help develop safer and more effective drug therapy with reduced side effects.

Timeline

Start

2011-12

Primary completion

2013-05

Completion

2013-12

Drugs

Indications

No indication recorded.