drugset / Trial / NCT01501786
Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions
RandomizedParallel-groupTriple-blindDiagnostic
Summary
Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.
Timeline
- Start
- 2012-01
- Primary completion
- 2013-05
- Completion
- 2013-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketamine | Small molecule | 10 ug/kg | — |
| Subject | Ketamine | Small molecule | 20 ug/kg | — |
| Subject | Propofol | Small molecule | 4.8 mg/kg | — |
| Subject | Propofol | Small molecule | 6.4 mg/kg | — |
| Subject | Propofol | Small molecule | 8 mg/kg | — |