drugset / Trial / NCT01501786

Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions

NCT01501786 ↗

Completed 150 enrolled Ibaraki Children's Hospital
RandomizedParallel-groupTriple-blindDiagnostic

Summary

Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.

Timeline

Start
2012-01
Primary completion
2013-05
Completion
2013-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Ketamine Small molecule 10 ug/kg —
Subject Ketamine Small molecule 20 ug/kg —
Subject Propofol Small molecule 4.8 mg/kg —
Subject Propofol Small molecule 6.4 mg/kg —
Subject Propofol Small molecule 8 mg/kg —