Efficacy of Low Dose hCG on Oocyte Maturity in Poor Responder Women Undergoing Intracytoplasmic Sperm Injection

Phase 3 Completed 73 enrolled Royan Institute

RandomizedParallel-groupOpen-labelTreatment

Summary

This study is a prospective, randomized, parallel, controlled trial to assess the efficacy of the late follicular phase administration of low dose hCG on oocyte maturity for ovarian stimulation in 73 poor respond patients undergoing intracytoplasmic sperm injection (ICSI) treatment.

Timeline

Start: 2009-10
Primary completion: 2011-03
Completion: 2011-12

Outcome

Missed primary endpoint

paper the number of metaphase II oocytes remains comparable between groups. PMID 22956348 ↗

Publications

Madani T, Mohammadi Yeganeh L, Khodabakhshi S, Akhoond MR, Hasani F. Efficacy of low dose hCG on oocyte maturity for ovarian stimulation in poor responder women undergoing intracytoplasmic sperm injection cycle: a randomized controlled trial. J Assist Reprod Genet. 2012 Nov;29(11):1213-20. doi: 10.1007/s10815-012-9854-3. Epub 2012 Sep 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	hCG	Unknown	100 iu	—
Subject	hCG	Unknown	200 iu	—
Background	Recombinant human follicle stimulating hormone (r-hFSH)	Protein / enzyme biologic	300 iu	—