drugset / Trial / NCT01514578
Single Ascending Dose Study of Intravenous TRV130A in Healthy Adult Males
RandomizedParallel-groupSingle-blindTreatment
Summary
This study will evaluate the safety, blood levels, and effects of TRV130A on pain perception and sedation in healthy adult males.
Timeline
- Start
- 2012-01
- Primary completion
- 2012-07
- Completion
- 2012-07
Publications
- Soergel DG, Subach RA, Sadler B, Connell J, Marion AS, Cowan CL, Violin JD, Lark MW. First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2014 Mar;54(3):351-7. doi: 10.1002/jcph.207. Epub 2014 Jan 28.
- Soergel DG, Subach RA, Cowan CL, Violin JD, Lark MW. First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2013 Sep;53(9):892-9. doi: 10.1002/jcph.111. Epub 2013 Jun 29.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | TRV130A | Unknown | 0.15 mg | Intravenous |
| Subject | TRV130A | Unknown | 1.5 mg | Intravenous |
| Subject | TRV130A | Unknown | 2.2 mg | Intravenous |
| Subject | TRV130A | Unknown | 4 mg | Intravenous |
| Subject | TRV130A | Unknown | 7 mg | Intravenous |
Indications
No indication recorded.