A Study to Investigate the Effect of YM150 on the Plasma Concentration of Digoxin in Healthy Subjects

Summary

This study is to evaluate the effect of YM150 on the plasma concentration of digoxin in healthy subjects.

Timeline

Start

2006-02

Primary completion

2006-04

Completion

2006-04

Outcome

Met primary endpoint

paper The 90 % CI for the GMRs fell within the limits of 0.80-1.25, indicating a lack of drug-drug interaction. PMID 23754514 ↗

Publications

• Kadokura T, Groenendaal D, Heeringa M, Mol R, Verheggen F, Garcia-Hernandez A, Onkels H. Darexaban (YM150), an oral direct factor Xa inhibitor, has no effect on the pharmacokinetics of digoxin. Eur J Drug Metab Pharmacokinet. 2014 Mar;39(1):1-9. doi: 10.1007/s13318-013-0141-1. Epub 2013 Jun 11.

Drugs

Indications

No indication recorded.