Comparison of Two Gelatine Solutions

Summary

The aim of volume replacement is to compensate a reduction in the intravascular volume e.g. during surgery and to counteract hypovolemia in order to maintain hemodynamics and vital functions. To achieve this, different plasma substitutes are available: Albumin, dextran, hydroxyethylstarches and gelatine. The aim of this study is to demonstrate that acid-base alterations during elective abdominal surgery can be reduced by the use of a new gelatine solution.

Timeline

Start

2011-12

Primary completion

2013-01

Completion

2013-01

Outcome

Met primary endpoint

paper demonstrated significant smaller impact on blood gas analytic parameters in the primary endpoints BE and serum chloride when compared to a non-balanced gelatine solution 4% combined with NaCl 0.9%. PMID 31034525 ↗

paper were significantly different (p = 0.0117 and p = 0.0045, respectively). PMID 31034525 ↗

Publications

• Marx G, Meybohm P, Schuerholz T, Lotz G, Ledinko M, Schindler AW, Rossaint R, Zacharowski K. Impact of a new balanced gelatine on electrolytes and pH in the perioperative care. PLoS One. 2019 Apr 29;14(4):e0213057. doi: 10.1371/journal.pone.0213057. eCollection 2019.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Gelofusine 4%	Unknown	—	Intravenous
Subject	Gelofusine balanced	Unknown	—	Intravenous
Subject	NaCl	Unknown	—	Intravenous
Subject	Sterofundin ISO	Other / unclassified	—	Intravenous

Indications

No indication recorded.