drugset / Trial / NCT01516957
AMG 827 in Subjects With Psoriatic Arthritis
RandomizedParallel-groupTriple-blindTreatment
Summary
The study will examine the safety and effectiveness of AMG 827 for the treatment of psoriatic arthritis
Timeline
- Start
- 2011-10
- Primary completion
- 2012-09
- Completion
- 2015-09
Publications
- Background Mease PJ, Genovese MC, Greenwald MW, Ritchlin CT, Beaulieu AD, Deodhar A, Newmark R, Feng J, Erondu N, Nirula A. Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis. N Engl J Med. 2014 Jun 12;370(24):2295-306. doi: 10.1056/NEJMoa1315231.
- Mease PJ, Genovese MC, Mutebi A, Viswanathan HN, Chau D, Feng J, Erondu N, Nirula A. Improvement in Psoriasis Signs and Symptoms Assessed by the Psoriasis Symptom Inventory with Brodalumab Treatment in Patients with Psoriatic Arthritis. J Rheumatol. 2016 Feb;43(2):343-9. doi: 10.3899/jrheum.150182. Epub 2016 Jan 15.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Brodalumab | Monoclonal antibody | 140 mg | Subcutaneous |
| Subject | Brodalumab | Monoclonal antibody | 210 mg | Subcutaneous |
| Subject | Brodalumab | Monoclonal antibody | 280 mg | Subcutaneous |