drugset / Trial / NCT01519037
Interaction Between a Calcimimetic Agent and the Renin Angiotensine Aldosterone System
Completed
18 enrolled
Centre Hospitalier Universitaire Vaudois
Swiss National Science Foundation · collab
RandomizedCrossoverQuadruple-blindBasic science
Summary
The aim of this study is to evaluate, in healthy volunteers, the acute modulating effect of cinacalcet on the RAAS, the effect of furosemide on parathyroid secretion of PTH and the interaction between furosemide and cinacalcet on parathyroid hormone secretion.
Timeline
- Start
- 2012-01
- Primary completion
- 2012-06
- Completion
- 2014-06
Publications
- Background Maillard MP, Tedjani A, Perregaux C, Burnier M. Calcium-sensing receptors modulate renin release in vivo and in vitro in the rat. J Hypertens. 2009 Oct;27(10):1980-7. doi: 10.1097/HJH.0b013e32832f0d22.
- Results Muller ME, Forni Ogna V, Maillard M, Stoudmann C, Zweiacker C, Anex C, Wuerzner G, Burnier M, Bonny O. Furosemide stimulation of parathormone in humans: role of the calcium-sensing receptor and the renin-angiotensin system. Pflugers Arch. 2015 Dec;467(12):2413-21. doi: 10.1007/s00424-015-1714-4. Epub 2015 Jun 20.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Cinacalcet | Other / unclassified | 60 mg | Oral |
Indications
No indication recorded.