CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug

Summary

Before and during bariatric surgery patients are given oral and i.v. midazolam, respectively and blood samples are drawn to establish midazolam time-concentration profiles. After 0.5-2 years, and substantial weight loss, oral and i.v. midazolam are administered once more and blood samples are taken again.

Timeline

Start

2011-12

Primary completion

2013-12

Completion

2013-12

Drugs

Indications