Daptomycin in Pediatric Patients With Bacterial Meningitis

Summary

5 Children \> 3months and \< 16 years with Gram-positive meningitis will receive a single dose of daptomycin 24 hours after the first dose of ceftriaxone. 4-8 hours after daptomycin administration a second lumbar puncture is performed to determine the peak concentration of daptomycin in the cerebrospinal fluid. In parallel peak and trough level of daptomycin will be measured in the plasma. The investigators anticipate that daptomycin penetrates into the cerebrospinal fluid in bactericidal concentrations

Timeline

Start

2012-04

Primary completion

2018-06-30

Completion

2018-06-30

Drugs

Indications