Mesenchymal Stromal Cells as Treatment of Chronic Graft-versus-host Disease

Phase 1 Terminated 11 enrolled Karolinska Institutet Region Stockholm · collab

NaSingle-groupOpen-labelTreatment

Summary

The aim of the study is to evaluate the safety and efficacy of mesenchymal stromal cells as treatment for steroid-refractory chronic graft-versus-host disease.

Timeline

Start: 2011-08
Primary completion: 2016-03
Completion: 2017-03

Publications

Boberg E, von Bahr L, Afram G, Lindstrom C, Ljungman P, Heldring N, Petzelbauer P, Garming Legert K, Kadri N, Le Blanc K. Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study. Stem Cells Transl Med. 2020 Oct;9(10):1190-1202. doi: 10.1002/sctm.20-0099. Epub 2020 Jun 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	mesenchymal stem cells	Cell therapy	1e+06 cells/kg	Intravenous
Subject	mesenchymal stem cells	Cell therapy	2e+06 cells/kg	Intravenous

Mesenchymal Stromal Cells as Treatment of Chronic Graft-versus-host Disease

Summary

Timeline

Publications

Drugs

Indications