drugset / Trial / NCT01526733
Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase
RandomizedCrossoverTriple-blindTreatment
Summary
The purpose of this study is to evaluate consistency of accelerated insulin absorption and onset-of-action and shortened duration of action for bolus insulin infusions after pretreatment with 150 units (U) of Hylenex® (recombinant human hyaluronidase PH20 \[rHuPH20\]) injection at the time of infusion set insertion compared to sham injection.
Timeline
- Start
- 2011-12
- Primary completion
- 2012-08
- Completion
- 2013-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | rHuPH20 | Protein / enzyme biologic | 150 iu | Other |
| Background | Insulin Lispro | Protein / enzyme biologic | 0.15 iu/kg | Subcutaneous |
| Background | insulin aspart | Protein / enzyme biologic | 0.15 iu/kg | Subcutaneous |