The Pharmacokinetic Study of Red Yeast Rice Capsule Compared to Lovastatin Tablet in Healthy Subjects

Phase 4 Completed 12 enrolled National Taiwan University Hospital National Science and Technology Council, Taiwan · collab

RandomizedCrossoverOpen-labelTreatment

Summary

The objective of the study is to evaluate the pharmacokinetics of lovastatin and lovastatin acid of four 600 mg LipoCol Forte capsules compared to that of one 20 mg lovastatin Tablet after single oral administration in healthy subjects.

Timeline

Start: 2012-02
Primary completion: 2012-02
Completion: 2012-02

Publications

Chen CH, Yang JC, Uang YS, Lin CJ. Improved dissolution rate and oral bioavailability of lovastatin in red yeast rice products. Int J Pharm. 2013 Feb 28;444(1-2):18-24. doi: 10.1016/j.ijpharm.2013.01.028. Epub 2013 Jan 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	LipoCol Forte	Unknown	2400 mg	Oral
Subject	Lovastatin	Small molecule	20 mg	Oral

Indications

No indication recorded.