drugset / Trial / NCT01530256
Exploratory Safety Study of ALD518 in Subjects With Steroid-refractory Acute Graft Versus Host Disease (GVHD)
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to determine the safe and tolerable, biologically active, and potentially effective doses(s) of ALD518 in subjects with acute GVHD, who have failed to respond to glucocorticosteroids, for further investigation in Part B.
Timeline
- Start
- 2012-03
- Primary completion
- 2013-03
- Completion
- 2013-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clazakizumab | Monoclonal antibody | 160 mg | Intravenous |
| Subject | Clazakizumab | Monoclonal antibody | 320 mg | Intravenous |
| Subject | Clazakizumab | Monoclonal antibody | 640 mg | Intravenous |