Atropin and Glucose Stimulated Insulinsecretion and the Cephalic Insulin Response

Unknown 10 enrolled University Hospital, Gentofte, Copenhagen University of Copenhagen · collab

RandomizedSingle-groupSingle-blindBasic science

Summary

The aim of this study is to investigate the role of transmission of vagal cholinerg for the GLP-1 potentiation of the glucose stimulated insulin secretion and the cephalic insulin response by using atropin administration. The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with an intact nervous supply with and without atropin administration.

Timeline

Start: 2011-09
Primary completion: 2012-12
Completion: 2012-12

Publications

Veedfald S, Plamboeck A, Deacon CF, Hartmann B, Knop FK, Vilsboll T, Holst JJ. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 1;310(1):G43-51. doi: 10.1152/ajpgi.00222.2015. Epub 2015 Oct 22.
Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Vilsboll T, Knop FK, Holst JJ. The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R544-51. doi: 10.1152/ajpregu.00123.2015. Epub 2015 Jul 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Atropine	Other / unclassified	80 unknown	—

Indications

No indication recorded.