The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence

Phase 1/2 Terminated 55 enrolled New York State Psychiatric Institute National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse prevention (MBRP) therapy, using a 5 week combined laboratory-inpatient and outpatient double-blind, randomized, controlled trial.

Timeline

Start: 2012-02
Primary completion: 2017-01
Completion: 2017-04

Publications

Dakwar E, Nunes EV, Hart CL, Foltin RW, Mathew SJ, Carpenter KM, Choi CJJ, Basaraba CN, Pavlicova M, Levin FR. A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial. Am J Psychiatry. 2019 Nov 1;176(11):923-930. doi: 10.1176/appi.ajp.2019.18101123. Epub 2019 Jun 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.5 mg/kg	Intravenous
Comparator	Midazolam	Small molecule	0.025 mg/kg	Intravenous

The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence

Summary

Timeline

Publications

Drugs

Indications