drugset / Trial / NCT01536249
Dexpramipexole and Cimetidine Drug Drug Interaction (DDI)
RandomizedCrossoverOpen-labelTreatment
Summary
This study will assess the effect of cimetidine on the pharmacokinetics (PK) of dexpramipexole in healthy volunteer and evaluate the safety and tolerability of dexpramipexole when given with or without cimetidine. Additionally, this study will explore the influence of genetic variation on the PK of dexpramipexole when given with or without cimetidine.
Timeline
- Start
- 2012-03
- Primary completion
- 2012-04
- Completion
- 2012-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cimetidine | Small molecule | 400 mg | Oral |
| Subject | Dexpramipexole | Small molecule | 300 mg | Oral |