Effect of Single Doses of YF476 on Stomach Acidity Compared With Ranitidine and Placebo in Fasted and Fed States

Summary

The objectives of the study were: * To compare a single dose of YF476 at 3 dose levels, placebo and ranitidine with respect to their effects on basal- and food- stimulated gastric pH in healthy volunteers. * To assess whether there is a relationship between the pharmacokinetics of YF476 and gastric pH in healthy volunteers. * To assess the safety and tolerability of single doses of YF476 in healthy volunteers.

Timeline

Start

1996-07

Primary completion

1996-08

Completion

1996-08

Publications

• Boyce M, David O, Darwin K, Mitchell T, Johnston A, Warrington S. Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects. Aliment Pharmacol Ther. 2012 Jul;36(2):181-9. doi: 10.1111/j.1365-2036.2012.05143.x. Epub 2012 May 20.

Drugs

Indications