Postoperative Analgesia Following Wisdom Teeth Removal: Ropivacaine Versus Placebo

Phase 4 Completed 100 enrolled Nîmes University Hospital

RandomizedParallel-groupTriple-blindTreatment

Summary

The main objective of this study is to demonstrate the superiority of local analgesia with ropivacaine versus placebo on postoperative pain during the first 24 hours following bilateral surgery of all four third molars under general anesthesia.

Timeline

Start: 2012-06
Primary completion: 2015-08-29
Completion: 2015-08-29

Outcome

Met primary endpoint

paper Area Under the Curve for VAS pain (0 to 4h) was lower for Ropivacaine group: 0.43 [0.19-0.66] vs. 0.63 [0.43-0.87], P=0.005. PMID 31326593 ↗

Publications

Results Ghezal H, Bouvet S, Kabani S, Ripart J, Cuvillon P. Ropivacaine versus placebo on postoperative analgesia and chronic pain following third molar extraction: A Prospective Randomized Controlled Study. J Stomatol Oral Maxillofac Surg. 2020 Apr;121(2):113-117. doi: 10.1016/j.jormas.2019.07.005. Epub 2019 Jul 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ropivacaine	Other / unclassified	2 ml	Other
Subject	Ropivacaine	Other / unclassified	7.5 mg/ml	Other

Indications

No indication recorded.