Study in Healthy Volunteers to Assess the Pharmacokinetics of Midazolam Administered Alone and in Combination With Vandetanib

Phase 1 Completed 16 enrolled Sanofi

Non-randomizedSingle-groupOpen-labelBasic science

Summary

The purpose of this study in healthy volunteers is to assess the Pharmacokinetics (PK) of Midazolam administered alone and in combination with Vandetanib.

Timeline

Start: 2012-04
Primary completion: 2012-07
Completion: 2012-07

Publications

Johansson S, Read J, Oliver S, Steinberg M, Li Y, Lisbon E, Mathews D, Leese PT, Martin P. Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine. Clin Pharmacokinet. 2014 Sep;53(9):837-47. doi: 10.1007/s40262-014-0161-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Midazolam	Small molecule	7.5 mg	Oral
Subject	Vandetanib	Small molecule	800 mg	Oral

Indications

No indication recorded.