Safety and Efficiency Study of Loading Dose Atorvastatin in Cardiac Surgery

Summary

Statins were reported to have pleiotropic effects including antiinflammatory, anti-oxidative stress effects and stabilise plaque in some conditions. Some researches indicate loading dose statin can reduce contrast induced nephropathy, and the levels of inflammatory markers were significantly decreased. The investigators hypothesis loading dose atorvastatin may attenuate inflammatory response during cardiopulmonary bypass (CPB) and therefore reduce postoperative acute kidney injury in cardiac surgery.

Timeline

Start

2012-04

Primary completion

2013-07

Completion

2013-07

Drugs

Indications