Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis

Summary

This study is intended to evaluate the efficacy and safety of Iguratimod alone or Iguratimod in combination with Methotrexate (MTX) versus Methotrexate alone in patients with Rheumatoid Arthritis (RA).

Timeline

Start

2012-05

Primary completion

2016-11

Completion

2017-01

Publications

• Du F, Dai Q, Teng J, Lu L, Ye S, Ye P, Lin Z, Ding H, Dai M, Bao C; SMILE Group. The SMILE study: Study of long-term methotrexate and iguratimod combination therapy in early rheumatoid arthritis. Chin Med J (Engl). 2025 Jul 20;138(14):1705-1713. doi: 10.1097/CM9.0000000000003200. Epub 2024 Jul 26.

Drugs

Indications