Effect of Adductor-Canal-Blockade on High Pain Responders After Total Knee Arthroplasty

Phase 4 Completed 50 enrolled University Hospital, Gentofte, Copenhagen

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether Adductor-Canal-Blockade (ACB) is superior to placebo when it comes to analgetic efficacy in high pain responders after Total Knee Arthroplasty (TKA). High pain responders are defined as patients reporting VAS \> 60 during knee flexion the 1. or 2. day after surgery.

Timeline

Start: 2012-02
Primary completion: 2012-12
Completion: 2012-12

Outcome

Met primary endpoint

paper A 32-mm difference in VAS pain score, during active flexion of the knee (primary endpoint), was observed in favour of Group A, 95% confidence interval (CI): 23-42, P<0.0001. PMID 24401802 ↗

Publications

Grevstad U, Mathiesen O, Lind T, Dahl JB. Effect of adductor canal block on pain in patients with severe pain after total knee arthroplasty: a randomized study with individual patient analysis. Br J Anaesth. 2014 May;112(5):912-9. doi: 10.1093/bja/aet441. Epub 2014 Jan 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ropivacaine	Other / unclassified	30 ml	Other

Indications

No indication recorded.