drugset / Trial / NCT01551459
A Phase II Study of Sunitinib Versus Dacarbazine in the Treatment of Patients With Metastatic Uveal Melanoma
Phase 2
Completed
124 enrolled
The Clatterbridge Cancer Centre NHS Foundation Trust
Cancer Research UK · collabPfizer · collab
RandomizedCrossoverOpen-labelTreatment
Summary
Doctors usually treat uveal melanoma with radiotherapy or surgery. But if this cancer spreads, it is more difficult to treat. Doctors usually treat uveal melanoma that has spread with a chemotherapy called dacarbazine, but they are always looking to find new ways to treat uveal melanoma. This study aims to find out how well Sunitinib works to treat uveal melanoma and to see how long Sunitinib and Dacarbazine can help to prevent the cancer from getting worse.
Timeline
- Start
- 2010-10
- Primary completion
- 2017-09
- Completion
- 2017-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dacarbazine | Small molecule | 1000 mg/m2 | Intravenous |
| Subject | Sunitinib | Small molecule | 50 mg | Oral |