drugset / Trial / NCT01554293
Study Of Single Ascending Doses Of PBL 1427 In Healthy Volunteers
RandomizedParallel-groupQuadruple-blindTreatment
Summary
PBL 1427 is a Dipeptidyl peptidase (DPP)-IV inhibitor being developed for treatment of type 2 diabetes. Although a number of DPP-IV inhibitors have been described, there still exists a need for new DPP-IV inhibitors that have better half-life, advantageous potency, stability and selectivity, less toxicity and/or better pharmacodynamic properties.
Timeline
- Start
- 2012-07
- Primary completion
- 2013-07
- Completion
- 2013-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | PBL 1427 | Unknown | 20 mg | Oral |
| Subject | PBL 1427 | Unknown | 40 mg | Oral |
| Subject | PBL 1427 | Unknown | 80 mg | Oral |
| Subject | PBL 1427 | Unknown | 150 mg | Oral |
| Subject | PBL 1427 | Unknown | 300 mg | Oral |
| Subject | PBL 1427 | Unknown | 600 mg | Oral |