Pharmacokinetics Of Tigecycline In Morbidly Obese Subjects

Summary

If tigecycline clearance increases with body size then serum exposure values will be lower in obese class III compared to normal weight subjects because exposure changes inversely with clearance when the dose is fixed without regard to weight.

Timeline

Start

2012-03

Primary completion

2012-05

Completion

2012-05

Publications

• Pai MP. Serum and urine pharmacokinetics of tigecycline in obese class III and normal weight adults. J Antimicrob Chemother. 2014 Jan;69(1):190-9. doi: 10.1093/jac/dkt299. Epub 2013 Jul 23.

Drugs

Indications