Efficacy and Safety of Parecoxib on Morphine Patient-controlled Epidural Analgesia (PCEA) After Gynecologic Surgery

Completed 294 enrolled Liu Weifeng Guangdong Provincial People's Hospital · collab Nanfang Hospital, Southern Medical University · collab Second Affiliated Hospital, Sun Yat-Sen University · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine the effects of parecoxib in combination with epidural morphine in providing analgesia for patients undergoing gynecological surgery.

Timeline

Start: 2009-06
Primary completion: 2010-05
Completion: 2010-05

Outcome

Met primary endpoint

paper Patients in the parecoxib group received significantly fewer self-administrated boluses (0 (0, 3) vs. 7 (2, 15), P < 0.001) PMID 27622453 ↗

Publications

Liu WF, Shu HH, Zhao GD, Peng SL, Xiao JF, Zhang GR, Liu KX, Huang WQ. Effect of Parecoxib as an Adjunct to Patient-Controlled Epidural Analgesia after Abdominal Hysterectomy: A Multicenter, Randomized, Placebo-Controlled Trial. PLoS One. 2016 Sep 13;11(9):e0162589. doi: 10.1371/journal.pone.0162589. eCollection 2016.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Parecoxib	Small molecule	40 mg	Intravenous