Evaluation of the Human Rotavirus Vaccine at Varying Schedules and Doses in Rural Ghana

Phase 4 Completed 456 enrolled PATH Centers for Disease Control and Prevention · collab Navrongo Health Research Centre, Ghana · collab Noguchi Memorial Institute for Medical Research · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

The purpose of this study is to determine whether giving the Human Rotavirus Vaccine on alternate dosing schedules will enhance the immune response to the vaccine in a low-resource, high-burden country in Africa. Alternate dosing schedules studied include giving the 2-dose vaccine schedule at a slightly older age and giving an additional dose of the vaccine.

Timeline

Start: 2012-09
Primary completion: 2013-02
Completion: 2013-02

Publications

Armah G, Lewis KD, Cortese MM, Parashar UD, Ansah A, Gazley L, Victor JC, McNeal MM, Binka F, Steele AD. A Randomized, Controlled Trial of the Impact of Alternative Dosing Schedules on the Immune Response to Human Rotavirus Vaccine in Rural Ghanaian Infants. J Infect Dis. 2016 Jun 1;213(11):1678-85. doi: 10.1093/infdis/jiw023. Epub 2016 Jan 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Rotarix	Vaccine	—	—

Evaluation of the Human Rotavirus Vaccine at Varying Schedules and Doses in Rural Ghana

Summary

Timeline

Publications

Drugs

Indications