A Phase 1 Crossover Study of Blood Pressure and Heart Rate Response

Phase 1 Completed 18 enrolled Merck & Co., Inc.

RandomizedCrossoverDouble-blindOther

Summary

This is a randomized, double-blinded, placebo-controlled, crossover study to evaluate the pressor effects of pseudoephedrine when administered with TR-701 FA in healthy adult volunteers.

Timeline

Start: 2012-04-23
Primary completion: 2012-06-15
Completion: 2012-06-15

Publications

Results Flanagan S, Minassian SL, Prokocimer P. Pharmacokinetics of Tedizolid and Pseudoephedrine Administered Alone or in Combination in Healthy Volunteers. J Clin Med. 2018 Jun 14;7(6):150. doi: 10.3390/jcm7060150.
Flanagan S, Bartizal K, Minassian SL, Fang E, Prokocimer P. In vitro, in vivo, and clinical studies of tedizolid to assess the potential for peripheral or central monoamine oxidase interactions. Antimicrob Agents Chemother. 2013 Jul;57(7):3060-6. doi: 10.1128/AAC.00431-13. Epub 2013 Apr 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pseudoephedrine	Small molecule	60 mg	Oral
Subject	Tedizolid	Small molecule	200 mg	Oral

Indications

No indication recorded.