ADIPOA - Clinical Study

Phase 1 Completed 18 enrolled University Hospital, Montpellier

Non-randomizedParallel-groupOpen-labelTreatment

Summary

Primary: To study the safety of a single injection of autologous adipose derived mesenchymal stromal cells (ASCs) on patients with moderate or severe osteoarthritis of the knee (OA). Secondary: To study the efficacy of a single injection of autologous adipose derived mesenchymal stromal cells on patients with moderate or severe osteoarthritis of the knee (OA).

Timeline

Start: 2012-04
Primary completion: 2014-12
Completion: 2014-12

Publications

Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P, Noel D, Canovas F, Cyteval C, Lisignoli G, Schrauth J, Haddad D, Domergue S, Noeth U, Jorgensen C; ADIPOA Consortium. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. Stem Cells Transl Med. 2016 Jul;5(7):847-56. doi: 10.5966/sctm.2015-0245. Epub 2016 May 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Autologous adipose derived stem cells	Cell therapy	2e+06 cells	Other
Subject	Autologous adipose derived stem cells	Cell therapy	1e+07 cells	Other
Subject	Autologous adipose derived stem cells	Cell therapy	5e+07 cells	Other

ADIPOA - Clinical Study

Summary

Timeline

Publications

Drugs

Indications