the Effect Site Equilibration Time of Propofol is Age Dependant

Phase 4 Completed 45 enrolled Universidad del Desarrollo

NaSingle-groupOpen-labelHealth-services research

Summary

This study obtains an effect site model for White (Modified Marsh) pharmacokinetic propofol model. The plasma effect-site rate constant (ke0) obtained is affected by age.

Timeline

Start: 2010-10
Primary completion: 2011-08
Completion: 2011-08

Publications

Background White M, Kenny GN, Schraag S. Use of target controlled infusion to derive age and gender covariates for propofol clearance. Clin Pharmacokinet. 2008;47(2):119-27. doi: 10.2165/00003088-200847020-00005.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	10 ug/ml	Intravenous
Subject	Propofol	Small molecule	12 ug/ml	Intravenous

Indications

No indication recorded.