Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation

Phase 4 Unknown 70 enrolled University of Manitoba

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The purpose of this study is to compare heart rate in infants who receive atropine as a part of their medication before intubation to those who do not. To be able to find out , we need to divided babies into 2 groups; group 1 : receives atropine + sedation + muscle relaxant group 2 : receives water or saline ( placebo group) + sedation + muscle relaxant Then we need to compare heart rate during intubation and duration of intubation between the 2 groups.

Timeline

Start: 2012-04
Primary completion: 2014-06
Completion: 2014-06

Publications

Afifi J, El-Naggar W, Hatfield T, Sandila N, Baier J, Narvey M. Atropine Versus Placebo for Neonatal Nonemergent Intubation: A Randomized Clinical Trial. J Pediatr. 2025 Nov;286:114719. doi: 10.1016/j.jpeds.2025.114719. Epub 2025 Jul 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Atropine	Other / unclassified	0.02 mg/kg	Intravenous

Indications

No indication recorded.