drugset / Trial / NCT01602185
Study of NMDA Antagonists and Neuropathic Pain
Phase 2
Completed
7 enrolled
University Hospital, Clermont-Ferrand
Dr Anne-Margot Duclot, Pain Clinic, Paris Rotschild Hospital · collabDr Géraldine Brumauld de Montgazon, Pain Clinic, La Rochelle Hospital · collabDr Malou Navez, Pain Clinic, Saint-Etienne Hopital · collabDr Marc Sorel, Pain Clinic, Nemours Hospital · collabDr Marie-Christine Crosmary/Dr Renato Colamarino, Pain Clinic, Vichy Hospital · collabDr Mohamed El Ayadi, Pain Clinic, Issoire Hospital · collabDr Monique Belon, Pain Clinic, Aurillac Hospital · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity. In clinical, after ketamine cure, clinicians have often difficulties to treat patients in order to maintain analgesia or suggest another treatment if analgesia induced by ketamine was not effective, which occurs in one quarter of patients. It will be very useful for monitoring of painful patients evaluate if memantine or dextromethorphan could be an effective therapeutic alternative in neuropathic pain treatment.
Timeline
- Start
- 2012-05
- Primary completion
- 2014-06
- Completion
- 2016-09-07
Publications
- Results Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary MC, Najjar M, Colamarino R, Creach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot MA, Narjoz C, Lambert C, Pereira B, Pickering G. Dextromethorphan and memantine after ketamine analgesia: a randomized control trial. Drug Des Devel Ther. 2019 Aug 2;13:2677-2688. doi: 10.2147/DDDT.S207350. eCollection 2019.
- Pickering G, Pereira B, Morel V, Tiberghien F, Martin E, Marcaillou F, Picard P, Delage N, de Montgazon G, Sorel M, Roux D, Dubray C. Rationale and design of a multicenter randomized clinical trial with memantine and dextromethorphan in ketamine-responder patients. Contemp Clin Trials. 2014 Jul;38(2):314-20. doi: 10.1016/j.cct.2014.06.004. Epub 2014 Jun 16.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dextromethorphan | Unknown | 90 mg | Oral |
| Subject | Memantine | Unknown | 20 mg | Oral |