Pharmacokinetic Study of Synera in Healthy Volunteers

Phase 1 Completed 12 enrolled ZARS Pharma Inc.

NaSingle-groupOpen-labelBasic science

Summary

This study will measure the amount of lidocaine and tetracaine in the blood after 2-, 4-, and 12-hour application of 4 Synera patches and a 4 hour application of 4 patches without heat.

Timeline

Start: 2010-02
Primary completion: 2010-03
Completion: 2010-03

Publications

Results Marriott TB, Charney MR, Stanworth S. Effects of application durations and heat on the pharmacokinetic properties of drug delivered by a lidocaine/tetracaine patch: a randomized, open-label, controlled study in healthy volunteers. Clin Ther. 2012 Oct;34(10):2174-83. doi: 10.1016/j.clinthera.2012.08.008. Epub 2012 Sep 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Synera	Unknown	70 mg	Topical

Indications

No indication recorded.