drugset / Trial / NCT01603251
Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission
Phase 1/2
Completed
120 enrolled
London School of Hygiene and Tropical Medicine
Centre national de recherche et de formation sur le paludisme · collabRadboud University Medical Center · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to determine the safety and impact of ivermectin, administered as single or repeated dose, in combination with artemether-lumefantrine in reducing the proportion of mosquitoes that survive and become infected after feeding on a blood meal from a malaria-infected individual.
Timeline
- Start
- 2013-01
- Primary completion
- 2013-04
- Completion
- 2013-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ivermectin | Small molecule | 200 ug/kg | — |
| Comparator | Artemether | Small molecule | — | — |
| Comparator | lumefantrine | Small molecule | — | — |