drugset / Trial / NCT01605344
Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI
RandomizedCrossoverOpen-labelBasic science
Summary
The purpose of this study is to evaluate the effect of atorvastatin on the pharmacokinetic profile of irinotecan and SN-38. To further evaluate the safety of atorvastatin in combination with FOLFIRI. To further evaluate the safety and of irinotecan in combination with atorvastatin.
Timeline
- Start
- 2012-04
- Primary completion
- 2013-07
- Completion
- 2014-07
Outcome
Outcome not reported
Stopped (Enrollment): “Study was withdrawn due to lack of patient enrollment.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 20 mg | Oral |
| Subject | Irinotecan | Small molecule | — | Other |
| Background | Leucovorin | Small molecule | — | Other |
| Background | fluorouracil | Small molecule | — | Other |