drugset / Trial / NCT01605435
Ghrelin Dose Finding In Frail Elderly
Non-randomizedParallel-groupSingle-blindOther
Summary
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty. Ghrelin is a hormone produced by the stomach that stimulates appetite centers in the brain. The purpose of this study is to determine the optimal subcutaneous ghrelin dose as a potential intervention for frail elderly individuals. We will examine food intake and metabolic parameters after placebo and ghrelin administration at three escalating subcutaneously administered doses.
Timeline
- Start
- 2012-05
- Primary completion
- 2012-12
- Completion
- 2012-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ghrelin | Peptide | 2 ug/kg | Subcutaneous |
| Subject | Ghrelin | Peptide | 5 ug/kg | Subcutaneous |
| Subject | Ghrelin | Peptide | 7.5 ug/kg | Subcutaneous |
| Subject | Ghrelin | Peptide | 10 ug/kg | Subcutaneous |
Indications
No indication recorded.